126.6K XNAS Volume
XNAS 19 Mar, 2025 10:21 AM (EDT)
| Client Name | Client Category | Action | Reported to Exchange | Quantity | Post Transaction Holding | Traded % | Avg. Price | Value | Security Type |
|---|---|---|---|---|---|---|---|---|---|
| Eric Schoen | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 3.82 per share. | 29 Nov 2024 | 2,000 | 0 (0%) | 0% | 3.8 | 7,640 | Common Stock |
| Schoen Eric | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Nov 2024 | 50,000 | 0 | - | - | Stock Option (Right to Buy) | |
| Eric Schoen | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 1.18 per share. | 29 Nov 2024 | 50,000 | 71,300 (0%) | 0% | 1.2 | 59,000 | Common Stock |
| Eric Schoen | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 3.86 per share. | 29 Nov 2024 | 59,800 | 11,500 (0%) | 0% | 3.9 | 230,828 | Common Stock |
| James Kupiec W. | Chief Medical Officer | Sale of securities on an exchange or to another person at price $ 3.87 per share. | 29 Nov 2024 | 4,000 | 0 (0%) | 0% | 3.9 | 15,480 | Common Stock |
| Jaren Landen | Chief Clinical Dev. Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Nov 2024 | 85,000 | 85,000 | - | - | Stock Option (Right to Buy) | |
| Freda Nassif | Chief Commercial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Nov 2024 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Richard J. Barry | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Oct 2024 | 600,000 | 600,000 | - | - | Stock Option (Right to Buy) | |
| Eric Schoen | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Sep 2024 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| James W. Kupiec | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Sep 2024 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Robert Christopher Cook | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Sep 2024 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Remi Barbier | Director, President & CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2024 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Eric Schoen | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2024 | 25,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| James W. Kupiec | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2024 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Robert Christopher Cook | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2024 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Sanford R. Robertson | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 16 May 2024 | 5,000 | 950,851 (5%) | 0% | 0 | Common Stock | |
| Sanford R. Robertson | Director | Gift of securities by or to the insider at price $ 0.00 per share. | 16 May 2024 | 5,000 | 5,000 (0%) | 0% | 0 | Common Stock | |
| Patrick J. Scannon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Sanford R. Robertson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Claude Nicaise | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Michael J. O'Donnell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Robert Z. Gussin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Richard J. Barry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 15,000 | 15,000 | - | - | Stock Option (Right to Buy) | |
| Pierre Gravier | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Robert Eugene Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 09 May 2024 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Sanford R. Robertson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.00 per share. | 26 Apr 2024 | 69,000 | 955,851 (5%) | 0% | 22 | 1,518,000 | Common Stock |
| Sanford R. Robertson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 26 Apr 2024 | 46,000 | 308,740 | - | - | Common Stock Warrant | |
| Sanford R. Robertson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2024 | 354,740 | 354,740 | - | - | Common Stock Warrant | |
| Sanford R. Robertson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 26 Apr 2024 | 72,000 | 72,000 | - | - | Common Stock Warrant | |
| Richard J. Barry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.00 per share. | 23 Apr 2024 | 176,085 | 469,562 (2%) | 1% | 22 | 3,873,870 | Common Stock |
| Richard J. Barry | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 23 Apr 2024 | 117,390 | 0 | - | - | Common Stock Warrant | |
| Richard J. Barry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Apr 2024 | 117,390 | 176,085 | - | - | Common Stock Warrant | |
| James W. Kupiec | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.00 per share. | 18 Apr 2024 | 1,500 | 4,000 (0%) | 0% | 22 | 33,000 | Common Stock |
| James W. Kupiec | Chief Medical Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Apr 2024 | 1,000 | 1,000 | - | - | Common Stock Warrant | |
| James W. Kupiec | Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 18 Apr 2024 | 1,000 | 0 | - | - | Common Stock Warrant | |
| Eric Schoen | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 22.00 per share. | 17 Apr 2024 | 1,500 | 21,300 (0%) | 0% | 22 | 33,000 | Common Stock |
| Eric Schoen | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Apr 2024 | 7,920 | 7,920 | - | - | Common Stock Warrant | |
| Eric Schoen | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Apr 2024 | 800 | 800 | - | - | Common Stock Warrant | |
| Eric Schoen | Chief Financial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Apr 2024 | 1,000 | 6,920 | - | - | Common Stock Warrant | |
| Eugene Robert Anderson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2023 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Sanford R. Robertson | Director | Purchase of securities on an exchange or from another person at price $ 17.45 per share. | 23 Aug 2023 | 30,000 | 886,851 (5%) | 0% | 17.5 | 523,500 | Common Stock |
| Richard J. Barry | Director | Purchase of securities on an exchange or from another person at price $ 16.65 per share. | 21 Aug 2023 | 16,571 | 293,477 (1%) | 0% | 16.6 | 275,907 | Common Stock |
| Richard J. Barry | Director | Purchase of securities on an exchange or from another person at price $ 16.80 per share. | 21 Aug 2023 | 1,906 | 276,906 (1%) | 0% | 16.8 | 32,021 | Common Stock |
| Patrick J. Scannon | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.95 per share. | 12 Jun 2023 | 1,000 | 1,000 (0%) | 0% | 1.0 | 950 | Common Stock |
| Patrick J. Scannon | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Jun 2023 | 1,000 | 9,000 | - | - | Stock Option (Right to Buy) | |
| Remi Barbier | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 25.25 per share. | 24 May 2023 | 9,545 | 380,852 (2%) | 0% | 25.2 | 241,011 | Common Stock |
| Remi Barbier | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 May 2023 | 71,428 | 0 | - | - | Stock Option (Right to Buy) | |
| Remi Barbier | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 24 May 2023 | 14,285 | 0 | - | - | Stock Option (Right to Buy) | |
| Remi Barbier | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 25.25 per share. | 24 May 2023 | 47,723 | 734,279 (4%) | 0% | 25.3 | 1,205,006 | Common Stock |
| Remi Barbier | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.87 per share. | 24 May 2023 | 71,428 | 782,002 (4%) | 0% | 16.9 | 1,204,990 | Common Stock |
| Remi Barbier | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.87 per share. | 24 May 2023 | 14,285 | 390,397 (2%) | 0% | 16.9 | 240,988 | Common Stock |
| Sanford R. Robertson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.60 per share. | 10 May 2023 | 3,571 | 851,138 (4%) | 0% | 19.6 | 69,992 | Common Stock |
| Sanford R. Robertson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2023 | 2,142 | 0 | - | - | Stock Opton (Right to Buy) | |
| Sanford R. Robertson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2023 | 3,571 | 0 | - | - | Stock Opton (Right to Buy) | |
| Sanford R. Robertson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 10 May 2023 | 3,571 | 0 | - | - | Stock Option (Right to Buy) | |
| Sanford R. Robertson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.66 per share. | 10 May 2023 | 2,142 | 856,851 (4%) | 0% | 16.7 | 35,686 | Common Stock |
| Sanford R. Robertson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.66 per share. | 10 May 2023 | 3,571 | 854,709 (4%) | 0% | 16.7 | 59,493 | Common Stock |
| Patrick J. Scannon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2023 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Sanford R. Robertson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2023 | 20,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Sanford R. Robertson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2023 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Michael J. O'Donnell | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2023 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Robert Z. Gussin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2023 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Robert Z. Gussin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2023 | 20,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Richard J. Barry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2023 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Richard J. Barry | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2023 | 20,000 | 25,000 | - | - | Stock Option (Right to Buy) | |
| Robert Z. Gussin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.60 per share. | 01 May 2023 | 3,571 | 17,694 (0%) | 0% | 19.6 | 69,992 | Common Stock |
| Robert Z. Gussin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.66 per share. | 01 May 2023 | 2,142 | 10,552 (0%) | 0% | 16.7 | 35,686 | Common Stock |
| Robert Z. Gussin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.66 per share. | 01 May 2023 | 3,571 | 14,123 (0%) | 0% | 16.7 | 59,493 | Common Stock |
| Robert Z. Gussin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2023 | 3,571 | 0 | - | - | Stock Option (Right to Buy) | |
| Robert Z. Gussin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2023 | 3,571 | 0 | - | - | Stock Option (Right to Buy) | |
| Robert Z. Gussin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2023 | 2,142 | 0 | - | - | Stock Option (Right to Buy) | |
| Robert Z. Gussin | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 23.34 per share. | 01 May 2023 | 7,077 | 10,617 (0%) | 0% | 23.3 | 165,177 | Common Stock |
| Michael J. O'Donnell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 19.60 per share. | 07 Mar 2023 | 3,571 | 12,012 (0%) | 0% | 19.6 | 69,992 | Common Stock |
| Michael J. O'Donnell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2023 | 3,571 | 0 | - | - | Stock Option (Right to Buy) | |
| Michael J. O'Donnell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 Mar 2023 | 3,571 | 0 | - | - | Stock Option (Right to Buy) | |
| Michael J. O'Donnell | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 25.20 per share. | 07 Mar 2023 | 2,778 | 6,873 (0%) | 0% | 25.2 | 70,006 | Common Stock |
| Michael J. O'Donnell | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 25.20 per share. | 07 Mar 2023 | 2,361 | 9,651 (0%) | 0% | 25.2 | 59,497 | Common Stock |
| Michael J. O'Donnell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.66 per share. | 07 Mar 2023 | 3,571 | 8,441 (0%) | 0% | 16.7 | 59,493 | Common Stock |
| Richard J. Barry | Director | Purchase of securities on an exchange or from another person at price $ 26.13 per share. | 06 Mar 2023 | 11,565 | 197,724 (1%) | 0% | 26.1 | 302,193 | Common Stock |
| Richard J. Barry | Director | Purchase of securities on an exchange or from another person at price $ 25.76 per share. | 06 Mar 2023 | 77,276 | 275,000 (1%) | 0% | 25.8 | 1,990,630 | Common Stock |
| Remi Barbier | Director, President and CEO | Other type of transaction at price $ 0.00 per share. | 31 Dec 2022 | 57,143 | 710,574 (4%) | 0% | 0 | Common Stock | |
| Nadav Friedmann | Director, Chief Medical Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 990 | 78,910 (0%) | 0% | 0 | Common Stock | |
| Nadav Friedmann | Director, Chief Medical Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2022 | 10 | 79,900 (0%) | 0% | 0 | Common Stock | |
| Robert Christopher Cook | SVP & General Counsel | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Oct 2022 | 100,000 | 100,000 | - | - | Employee Stock Option (right to buy) | |
| Nadav Friedmann | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 03 Oct 2022 | 9,376 | 40,624 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.95 per share. | 03 Oct 2022 | 9,376 | 79,910 (0%) | 0% | 0.9 | 8,907 | Common Stock |
| Sanford R. Robertson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.59 per share. | 08 Sep 2022 | 2,802 | 1,027,567 (5%) | 0% | 23.6 | 66,099 | Common Stock |
| Sanford R. Robertson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 Sep 2022 | 2,802 | 0 | - | - | Common Stock | |
| Richard J. Barry | Director | Purchase of securities on an exchange or from another person at price $ 23.79 per share. | 23 Aug 2022 | 36,159 | 186,159 (1%) | 0% | 23.8 | 860,223 | Common Stock |
| James Kupiec | Chief Clinical Dev. Officer | Purchase of securities on an exchange or from another person at price $ 24.44 per share. | 23 Aug 2022 | 2,500 | 2,500 (0%) | 0% | 24.4 | 61,100 | Common Stock |
| Sanford R. Robertson | Director | Purchase of securities on an exchange or from another person at price $ 20.69 per share. | 12 Aug 2022 | 100,000 | 1,024,765 (5%) | 0% | 20.7 | 2,069,000 | Common Stock |
| Eric Schoen | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 19.95 per share. | 12 Aug 2022 | 2,500 | 19,800 (0%) | 0% | 20.0 | 49,875 | Common Stock |
| Remi Barbier | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.38 per share. | 06 Jun 2022 | 65,368 | 822,437 (4%) | 0% | 23.4 | 1,528,304 | Common Stock |
| Remi Barbier | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 27.93 per share. | 06 Jun 2022 | 54,720 | 767,717 (4%) | 0% | 27.9 | 1,528,330 | Common Stock |
| Remi Barbier | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 06 Jun 2022 | 65,368 | 0 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.38 per share. | 27 May 2022 | 3,501 | 70,590 (0%) | 0% | 23.4 | 81,853 | Common Stock |
| Nadav Friedmann | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 May 2022 | 24,513 | 0 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.66 per share. | 27 May 2022 | 21,498 | 70,534 (0%) | 0% | 26.7 | 573,137 | Common Stock |
| Nadav Friedmann | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 May 2022 | 3,501 | 0 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 26.66 per share. | 27 May 2022 | 3,071 | 92,032 (0%) | 0% | 26.7 | 81,873 | Common Stock |
| Nadav Friedmann | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.38 per share. | 27 May 2022 | 24,513 | 95,103 (0%) | 0% | 23.4 | 573,114 | Common Stock |
| Remi Barbier | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 16.31 per share. | 25 Apr 2022 | 4,669 | 376,112 (2%) | 0% | 16.3 | 76,151 | Common Stock |
| Remi Barbier | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Apr 2022 | 4,669 | 0 | - | - | Common Stock | |
| Remi Barbier | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Apr 2022 | 44,791 | 5,209 | - | - | Common Stock | |
| Remi Barbier | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.95 per share. | 25 Apr 2022 | 44,791 | 371,443 (2%) | 0% | 0.9 | 42,551 | Common Stock |
| Robert Z. Gussin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 23.59 per share. | 29 Mar 2022 | 2,801 | 12,434 (0%) | 0% | 23.6 | 66,076 | Common Stock |
| Robert Z. Gussin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 20.30 per share. | 29 Mar 2022 | 4,669 | 9,633 (0%) | 0% | 20.3 | 94,781 | Common Stock |
| Robert Z. Gussin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Mar 2022 | 2,801 | 0 | - | - | Common Stock | |
| Robert Z. Gussin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 29 Mar 2022 | 4,669 | 0 | - | - | Common Stock | |
| Robert Z. Gussin | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 39.98 per share. | 29 Mar 2022 | 4,024 | 8,410 (0%) | 0% | 40.0 | 160,880 | Common Stock |
| Sanford R. Robertson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 25 Mar 2022 | 4,670 | 0 | - | - | Common Stock | |
| Sanford R. Robertson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 20.30 per share. | 25 Mar 2022 | 4,670 | 924,765 (5%) | 0% | 20.3 | 94,801 | Common Stock |
| Robert Z. Gussin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 15 Sep 2021 | 2,801 | 0 | - | - | Common Stock | |
| Robert Z. Gussin | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.37 per share. | 15 Sep 2021 | 2,801 | 6,710 (0%) | 0% | 27.4 | 76,663 | Common Stock |
| Robert Z. Gussin | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 43.92 per share. | 15 Sep 2021 | 1,746 | 4,964 (0%) | 0% | 43.9 | 76,684 | Common Stock |
| Remi Barbier | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 20 Jul 2021 | 2,801 | 0 | - | - | Common Stock | |
| Remi Barbier | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 20.23 per share. | 20 Jul 2021 | 2,801 | 326,652 (1%) | 0% | 20.2 | 56,664 | Common Stock |
| Remi Barbier | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 May 2021 | 56,030 | 0 | - | - | Common Stock | |
| Remi Barbier | Director, President and CEO | Payment of exercise price or tax liability using portion of securities received from the company at price $ 55.60 per share. | 27 May 2021 | 53,965 | 1,080,920 (6%) | 0% | 55.6 | 3,000,454 | Common Stock |
| Remi Barbier | Director, President and CEO | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.55 per share. | 27 May 2021 | 56,030 | 1,134,885 (6%) | 0% | 53.6 | 3,000,407 | Common Stock |
| Sanford R. Robertson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Mar 2021 | 4,670 | 0 | - | - | Common Stock | |
| Sanford R. Robertson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 27.37 per share. | 30 Mar 2021 | 2,802 | 915,425 (5%) | 0% | 27.4 | 76,691 | Common Stock |
| Sanford R. Robertson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 49.00 per share. | 30 Mar 2021 | 4,670 | 920,095 (5%) | 0% | 49 | 228,830 | Common Stock |
| Sanford R. Robertson | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 30 Mar 2021 | 2,802 | 0 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 17 Mar 2021 | 28,015 | 0 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Medical Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 62.52 per share. | 17 Mar 2021 | 23,996 | 68,429 (0%) | 0% | 62.5 | 1,500,230 | Common Stock |
| Nadav Friedmann | Director, Chief Medical Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 53.55 per share. | 17 Mar 2021 | 28,015 | 92,428 (0%) | 0% | 53.5 | 1,500,203 | Common Stock |
| Michael J. O'Donnell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 49.00 per share. | 16 Mar 2021 | 4,669 | 9,257 (0%) | 0% | 49 | 228,781 | Common Stock |
| Michael J. O'Donnell | Director | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 16 Mar 2021 | 4,669 | 0 | - | - | Common Stock | |
| Michael J. O'Donnell | Director | Payment of exercise price or tax liability using portion of securities received from the company at price $ 52.16 per share. | 16 Mar 2021 | 4,387 | 4,870 (0%) | 0% | 52.2 | 228,826 | Common Stock |
| Patrick J. Scannon | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2020 | 5,000 | 5,000 | - | - | Stock Option (Right to Buy) | |
| Sanford R. Robertson | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2020 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Robert Z. Gussin | Director | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2020 | 10,000 | 10,000 | - | - | Stock Option (Right to Buy) | |
| Remi Barbier | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 9.59 per share. | 24 Sep 2020 | 10,000 | 1,078,855 (6%) | 0% | 9.6 | 95,900 | Common Stock |
| Sanford R. Robertson | Director | Purchase of securities on an exchange or from another person at price $ 8.92 per share. | 18 Sep 2020 | 36,281 | 912,623 (5%) | 0% | 8.9 | 323,627 | Common Stock |
| Sanford R. Robertson | Director | Purchase of securities on an exchange or from another person at price $ 6.98 per share. | 17 Sep 2020 | 213,719 | 876,342 (5%) | 1% | 7.0 | 1,491,759 | Common Stock |
| Eric Schoen | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 7.04 per share. | 17 Sep 2020 | 2,000 | 27,300 (0%) | 0% | 7.0 | 14,080 | Common Stock |
| Eric Schoen | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 7.03 per share. | 17 Sep 2020 | 10,000 | 25,300 (0%) | 0% | 7.0 | 70,300 | Common Stock |
| Remi Barbier | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 5.53 per share. | 31 Dec 2019 | 100,000 | 1,068,855 (6%) | 0% | 5.5 | 553,000 | Common Stock |
| Remi Barbier | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 4.15 per share. | 26 Dec 2019 | 10,000 | 968,855 (5%) | 0% | 4.2 | 41,500 | Common Stock |
| Sanford R. Robertson | None | Purchase of securities on an exchange or from another person at price $ 2.20 per share. | 20 Dec 2019 | 423,788 | 662,623 (3%) | 2% | 2.2 | 932,334 | Common Stock |
| Sanford R. Robertson | None | Purchase of securities on an exchange or from another person at price $ 1.86 per share. | 19 Dec 2019 | 76,212 | 238,835 (1%) | 0% | 1.9 | 141,754 | Common Stock |
| Eric Schoen | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 1.88 per share. | 19 Dec 2019 | 5,300 | 15,300 (0%) | 0% | 1.9 | 9,964 | Common Stock |
| Remi Barbier | Director, President and CEO | Purchase of securities on an exchange or from another person at price $ 1.65 per share. | 18 Dec 2019 | 2,599 | 958,855 (5%) | 0% | 1.6 | 4,288 | Common Stock |
| Patrick J. Scannon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2019 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Remi Barbier | Director, President and CEO | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2019 | 100,000 | 100,000 | - | - | Stock Option (Right to Buy) | |
| Nadav Friedmann | Director, Chief Medical & Operating Off. | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2019 | 50,000 | 50,000 | - | - | Stock Option (Right to Buy) | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2019 | 40,000 | 40,000 | - | - | Stock Option (Right to Buy) | |
| Michael J. O'Donnell | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2019 | 20,000 | 20,000 | - | - | Stock Option (Right to Buy) | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2019 | 40,000 | 40,000 | - | - | Stock option (Right to Buy) | |
| Saira Ramasastry | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Dec 2019 | 30,000 | 30,000 | - | - | Stock Option (Right to Buy) | |
| Eric Schoen | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Oct 2018 | 50,000 | 50,000 | - | - | Common Stock (1) | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 28 Sep 2018 | 60,000 | 60,000 | - | - | Stock Options(1) | |
| Sanford R. Robertson | None | Purchase of securities on an exchange or from another person at price $ 1.05 per share. | 27 Sep 2018 | 37,817 | 162,623 (0%) | 0% | 1.1 | 39,708 | Common Stock |
| Sanford R. Robertson | None | Purchase of securities on an exchange or from another person at price $ 1.00 per share. | 24 Sep 2018 | 21,420 | 93,814 (0%) | 0% | 1 | 21,420 | Common Stock |
| Sanford R. Robertson | None | Purchase of securities on an exchange or from another person at price $ 1.05 per share. | 24 Sep 2018 | 30,992 | 124,806 (0%) | 0% | 1.1 | 32,542 | Common Stock |
| Sanford R. Robertson | None | Purchase of securities on an exchange or from another person at price $ 0.96 per share. | 24 Sep 2018 | 9,771 | 72,394 (0%) | 0% | 1.0 | 9,380 | Common Stock |
| Patrick J. Scannon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Sep 2018 | 10,000 | 107,400 | - | - | Stock Options(1) | |
| Nadav Friedmann | Director, Chief Sientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Sep 2018 | 50,000 | 600,993 | - | - | Stock Options(1) | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Sep 2018 | 15,000 | 128,472 | - | - | Stock Options(1) | |
| Michael J. O'Donnell | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Sep 2018 | 10,000 | 94,446 | - | - | Stock Options(1) | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Sep 2018 | 15,000 | 128,468 | - | - | Stock Options(1) | |
| Saira Ramasastry | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Sep 2018 | 15,000 | 94,991 | - | - | Stock Options(1) | |
| Michael J. O'Donnell | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2017 | 20,000 | 90,574 | - | - | Non-Qualifying Stock Options (1) | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2017 | 25,000 | 123,272 | - | - | Non-Qualifying Stock Options (1) | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2017 | 25,000 | 123,276 | - | - | Non-Qualifying Stock Options (1) | |
| Patrick J. Scannon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2017 | 20,000 | 107,204 | - | - | Non-Qualifying Stock Options (1) | |
| Saira Ramasastry | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Dec 2017 | 22,500 | 79,991 | - | - | Non-Qualifying Stock Options (1) | |
| Nadav Friedmann | Director, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Aug 2017 | 250,000 | 639,238 | - | - | Stock Options(1) | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Aug 2017 | 300,000 | 976,714 | - | - | Stock Options(1) | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2017 | 2,500 | 108,090 | - | - | Non-Qualifying Stock Options (1) | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2017 | 2,500 | 108,090 | - | - | Non-Qualifying Stock Options (1) | |
| Saira Ramasastry | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Jun 2017 | 2,500 | 57,500 | - | - | Non-Qualifying Stock Options (1) | |
| Michael J. O'Donnell | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2017 | 50,000 | 536,956 | - | - | Non-Qualifying Stock Options (1) | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2017 | 50,000 | 739,128 | - | - | Non-Qualifying Stock Options (1) | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2017 | 50,000 | 739,128 | - | - | Non-Qualifying Stock Options (1) | |
| Patrick J. Scannon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2017 | 50,000 | 679,128 | - | - | Non-Qualifying Stock Options (1) | |
| Saira Ramasastry | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 04 May 2017 | 50,000 | 385,000 | - | - | Non-Qualifying Stock Options (1) | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2016 | 15,000 | 714,866 | - | - | Non-Qualifying Stock Options (1) | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2016 | 15,000 | 714,866 | - | - | Non-Qualifying Stock Options (1) | |
| Saira Ramasastry | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 24 Jun 2016 | 15,000 | 335,000 | - | - | Non-Qualifying Stock Options (1) | |
| Michael J. O'Donnell | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 May 2016 | 50,000 | 529,853 | - | - | Non-Qualifying Stock Options (1) | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 May 2016 | 50,000 | 742,763 | - | - | Non-Qualifying Stock Options (1) | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 May 2016 | 50,000 | 742,763 | - | - | Non-Qualifying Stock Options (1) | |
| Patrick J. Scannon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 May 2016 | 50,000 | 629,128 | - | - | Non-Qualifying Stock Options (1) | |
| Saira Ramasastry | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 May 2016 | 50,000 | 320,000 | - | - | Non-Qualifying Stock Options (1) | |
| Nadav Friedmann | Director, Chief Operating Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 08 Apr 2016 | 10,000 | 349,893 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Apr 2016 | 100,000 | 449,893 | - | - | Common Stock | |
| Peter S. Roddy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Apr 2016 | 18,386 | 121,479 | - | - | Common Stock | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Apr 2016 | 145,300 | 4,515,031 | - | - | Common Stock | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Apr 2016 | 25,000 | 126,262 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2015 | 300,000 | 3,711,350 | - | - | Stock Options(1) | |
| Peter S. Roddy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2015 | 150,000 | 1,666,722 | - | - | Stock Options(1) | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Dec 2015 | 600,000 | 5,809,482 | - | - | Stock Options(1) | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2015 | 15,000 | 692,763 | - | - | Non-Qualifying Stock Options (1) | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2015 | 15,000 | 692,763 | - | - | Non-Qualifying Stock Options (1) | |
| Saira Ramasastry | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 Jun 2015 | 15,000 | 270,000 | - | - | Non-Qualifying Stock Options (1) | |
| Michael J. O'Donnell | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2015 | 50,000 | 522,750 | - | - | Non-Qualifying Stock Options (1) | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2015 | 50,000 | 746,398 | - | - | Non-Qualifying Stock Options (1) | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2015 | 50,000 | 746,398 | - | - | Non-Qualifying Stock Options (1) | |
| Patrick J. Scannon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2015 | 50,000 | 579,128 | - | - | Non-Qualifying Stock Options (1) | |
| Saira Ramasastry | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 May 2015 | 50,000 | 255,000 | - | - | Non-Qualifying Stock Options (1) | |
| Michael J. O'Donnell | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2014 | 50,000 | 472,750 | - | - | Non-Qualifying Stock Options (1) | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2014 | 50,000 | 722,136 | - | - | Non-Qualifying Stock Options (1) | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2014 | 50,000 | 696,398 | - | - | Non-Qualifying Stock Options (1) | |
| Saira Ramasastry | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 12 Dec 2014 | 50,000 | 205,000 | - | - | Non-Qualifying Stock Options (1) | |
| Nadav Friedmann | Director, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Nov 2014 | 300,000 | 3,754,535 | - | - | Stock Options(1) | |
| Nadav Friedmann | Director, Chief Operating Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 18 Nov 2014 | 5,000 | 359,893 | - | - | Common Stock | |
| Peter S. Roddy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Nov 2014 | 150,000 | 1,731,212 | - | - | Stock Options(1) | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 18 Nov 2014 | 600,000 | 5,724,260 | - | - | Stock Options(1) | |
| Peter S. Roddy | chief Fianancial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jul 2014 | 171,591 | 256,143 | - | - | Common Stock | |
| Peter S. Roddy | chief Fianancial Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 14 Jul 2014 | 153,050 | 103,093 | - | - | Common Stock | |
| Peter S. Roddy | chief Fianancial Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jul 2014 | 171,591 | 1,581,212 | - | - | Common Stock | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 14 Jul 2014 | 382,981 | 4,369,731 | - | - | Common Stock | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jul 2014 | 428,981 | 5,124,260 | - | - | Common Stock | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 14 Jul 2014 | 428,981 | 4,752,359 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Jul 2014 | 128,693 | 1,001,880 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 11 Jul 2014 | 117,323 | 78,551 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 11 Jul 2014 | 128,693 | 195,874 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2014 | 135,334 | 471,563 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 01 Jul 2014 | 106,670 | 364,893 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jul 2014 | 135,334 | 3,454,535 | - | - | Common Stock | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2014 | 15,000 | 672,136 | - | - | Non-Qualifying Stock Options (1) | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2014 | 15,000 | 646,398 | - | - | Non-Qualifying Stock Options (1) | |
| Saira Ramasastry | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 13 Jun 2014 | 15,000 | 155,000 | - | - | Non-Qualifying Stock Options (1) | |
| Grant L. Schoenhard | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2014 | 70,000 | 1,130,573 | - | - | Stock Options(1) | |
| Nadav Friedmann | Director, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2014 | 300,000 | 3,589,869 | - | - | Stock Options(1) | |
| Peter S. Roddy | chief Fianancial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2014 | 150,000 | 1,752,803 | - | - | Stock Options(1) | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 06 Jun 2014 | 600,000 | 5,553,241 | - | - | Stock Options(1) | |
| Robert Z. Gussin | None | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 27 May 2014 | 39,069 | 27,360 | - | - | Common Stock | |
| Robert Z. Gussin | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 May 2014 | 42,897 | 657,136 | - | - | Common Stock | |
| Robert Z. Gussin | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 27 May 2014 | 42,897 | 66,429 | - | - | Common Stock | |
| Michael J. O'Donnell | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2014 | 50,000 | 422,750 | - | - | Non-Qualifying Stock Options (1) | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2014 | 50,000 | 700,033 | - | - | Non-Qualifying Stock Options (1) | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2014 | 50,000 | 631,398 | - | - | Non-Qualifying Stock Options (1) | |
| Patrick J. Scannon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2014 | 50,000 | 479,128 | - | - | Non-Qualifying Stock Options (1) | |
| Saira Ramasastry | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2014 | 50,000 | 140,000 | - | - | Non-Qualifying Stock Options (1) | |
| Nadav Friedmann | Director, Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Apr 2014 | 122,054 | 434,304 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 09 Apr 2014 | 98,075 | 336,229 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 09 Apr 2014 | 122,054 | 3,289,869 | - | - | Common Stock | |
| Michael J. O'Donnell | None | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 21 Mar 2014 | 34,830 | 32,118 | - | - | Common Stock | |
| Michael J. O'Donnell | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Mar 2014 | 42,897 | 66,948 | - | - | Common Stock | |
| Michael J. O'Donnell | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Mar 2014 | 42,897 | 372,750 | - | - | Common Stock | |
| Sanford R. Robertson | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Mar 2014 | 25,738 | 438,362 | - | - | (1) Common Stock | |
| Sanford R. Robertson | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Mar 2014 | 42,897 | 607,136 | - | - | (1) Common Stock | |
| Sanford R. Robertson | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Mar 2014 | 42,897 | 412,624 | - | - | (1) Common Stock | |
| Sanford R. Robertson | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 21 Mar 2014 | 25,738 | 581,398 | - | - | (1) Common Stock | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 12 Dec 2013 | 39,637 | 2,153,762 | - | - | Common Stock | |
| Sanford R. Robertson | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 04 Nov 2013 | 18,162 | 337,889 | - | - | Common Stock | |
| Sanford R. Robertson | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 04 Nov 2013 | 31,838 | 369,727 | - | - | Common stock | |
| Michael J. O'Donnell | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2013 | 25,000 | 415,647 | - | - | Non-Qualifying Stock Options (1) | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2013 | 25,000 | 635,033 | - | - | Non-Qualifying Stock Options (1) | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2013 | 15,000 | 650,033 | - | - | Non-Qualifying Stock Options (2) | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2013 | 15,000 | 675,771 | - | - | Non-Qualifying Stock Options (2) | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2013 | 25,000 | 660,771 | - | - | Non-Qualifying Stock Options (1) | |
| Patrick J. Scannon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2013 | 25,000 | 429,128 | - | - | Non-Qualifying Stock Options (1) | |
| Saira Ramasastry | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2013 | 15,000 | 90,000 | - | - | Non-Qualifying Stock Options (2) | |
| Saira Ramasastry | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Jun 2013 | 25,000 | 75,000 | - | - | Non-Qualifying Stock Options (1) | |
| Grant L. Schoenhard | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2013 | 150,000 | 1,272,489 | - | - | Stock Options (1) | |
| Nadav Friedmann | Director, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2013 | 300,000 | 3,626,413 | - | - | Stock Options (1) | |
| Peter S. Roddy | Cheif Fianancial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2013 | 150,000 | 1,688,598 | - | - | Stock Options (1) | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 05 Jun 2013 | 500,000 | 5,296,425 | - | - | Stock Options (1) | |
| Michael J. O'Donnell | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2013 | 25,000 | 390,557 | - | - | Non-Qualifying Stock Options(1) | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2013 | 25,000 | 610,033 | - | - | Non_Qualifying Stock Options (1) | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2013 | 25,000 | 635,771 | - | - | Non-Qualifying Stock Options(1) | |
| Patrick J. Scannon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2013 | 25,000 | 404,128 | - | - | Non-Qualifying Stock Options (1) | |
| Saira Ramasastry | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 May 2013 | 25,000 | 50,000 | - | - | Non-Qualifying Stock Options (1) | |
| Robert Z. Gussin | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 May 2013 | 42,897 | 48,748 | - | - | Common Stock | |
| Robert Z. Gussin | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 May 2013 | 42,897 | 585,033 | - | - | Common Stock | |
| Robert Z. Gussin | None | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 08 May 2013 | 32,510 | 23,532 | - | - | Common Stock | |
| Robert Z. Gussin | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 May 2013 | 42,897 | 56,042 | - | - | Common Stock | |
| Robert Z. Gussin | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 May 2013 | 25,738 | 670,827 | - | - | Common Stock | |
| Robert Z. Gussin | None | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 08 May 2013 | 35,603 | 13,145 | - | - | Common Stock | |
| Robert Z. Gussin | None | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 08 May 2013 | 19,887 | 5,851 | - | - | Common Stock | |
| Robert Z. Gussin | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 May 2013 | 25,738 | 25,738 | - | - | Common Stock | |
| Robert Z. Gussin | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 08 May 2013 | 42,897 | 627,930 | - | - | Common Stock | |
| Michael J. O'Donnell | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 May 2013 | 42,897 | 56,995 | - | - | Common Stock | |
| Michael J. O'Donnell | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 07 May 2013 | 42,897 | 365,557 | - | - | Common Stock | |
| Michael J. O'Donnell | None | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 07 May 2013 | 32,904 | 24,051 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | Other type of transaction at price $ 0.00 per share. | 01 May 2013 | 650 | 67,181 | - | - | (1) Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Other type of transaction at price $ 0.00 per share. | 01 May 2013 | 6,507 | 312,250 | - | - | (1) Common Stock | |
| Peter S. Roddy | Cheif Fianancial Officer | Other type of transaction at price $ 0.00 per share. | 01 May 2013 | 2,604 | 84,552 | - | - | (1) Common Stock | |
| Sanford R. Robertson | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2013 | 42,897 | 319,727 | - | - | (1) Common Stock | |
| Sanford R. Robertson | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 May 2013 | 42,897 | 610,771 | - | - | (1) Common Stock | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2012 | 1,500 | 4,323,378 | - | - | Common Stock (1) | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2012 | 37,400 | 4,323,378 | - | - | Common Stock | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2012 | 2,000,000 | 4,323,378 | - | - | Common stock (2) | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2012 | 2,700 | 2,114,125 | - | - | Common Stock (1) | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2012 | 13,600 | 2,114,125 | - | - | Common Stock | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Dec 2012 | 2,000,000 | 2,114,125 | - | - | Common Stock (2) | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Dec 2012 | 3,533 | 96,283 | - | - | Common Stock (1) | |
| Nadav Friedmann | Director, Chief Operating Officer | Other type of transaction at price $ 0.00 per share. | 01 Nov 2012 | 2,108 | 330,743 | - | - | (1) Common Stock | |
| Peter S. Roddy | Chief Fiancial Officer | Other type of transaction at price $ 0.00 per share. | 01 Nov 2012 | 596 | 81,948 | - | - | Common Stock (1) | |
| Grant L. Schoenhard | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Oct 2012 | 11,032 | 66,531 | - | - | Common Stock (1) | |
| Nadav Friedmann | Director, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Oct 2012 | 55,162 | 328,635 | - | - | Common Stock (1) | |
| Peter S. Roddy | Chief Fnancial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Oct 2012 | 11,032 | 81,352 | - | - | Common Stock (1) | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Oct 2012 | 110,325 | 6,103,378 | - | - | Common Stock (1) | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Oct 2012 | 36,775 | 92,750 | - | - | Common Stock (1) | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Sep 2012 | 15,000 | 532,804 | - | - | Non-Qualified Stock Options (1) | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Sep 2012 | 15,000 | 499,992 | - | - | Non-Qualified Stock Options (1) | |
| Patrick J. Scannon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 14 Sep 2012 | 15,000 | 289,996 | - | - | Non-Qualified Stock Options (1) | |
| Grant L. Schoenhard | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2012 | 70,000 | 924,212 | - | - | Stock Option (1) | |
| Nadav Friedmann | Director, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2012 | 150,000 | 2,609,972 | - | - | Stock Options (1) | |
| Peter S. Roddy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2012 | 70,000 | 1,176,866 | - | - | Stock Options (1) | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 08 Jun 2012 | 350,000 | 3,668,743 | - | - | Stock Options (1) | |
| Michael J. O'Donnell | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2012 | 25,000 | 345,308 | - | - | Non-Qualifying Stock Options(1) | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2012 | 25,000 | 517,804 | - | - | Non-Qualified Stock Options(1) | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2012 | 25,000 | 517,804 | - | - | Non-Qualifying Stock Options(1) | |
| Patrick J. Scannon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 May 2012 | 25,000 | 274,996 | - | - | Non-Qualifying Stock Options(1) | |
| Nadav Friedmann | Director, Chief Operating Officer | Other type of transaction at price $ 0.00 per share. | 01 May 2012 | 3,622 | 273,473 | - | - | Common Stock (1) | |
| Peter S. Roddy | Chief Financial Officer | Other type of transaction at price $ 0.00 per share. | 01 May 2012 | 4,346 | 70,320 | - | - | Common stock (1) | |
| Nadav Friedmann | Director, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2011 | 10,000 | 269,851 | - | - | Common Stock (1) | |
| Peter S. Roddy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2011 | 11,032 | 65,974 | - | - | Common stock (1) | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Dec 2011 | 45,000 | 5,993,053 | - | - | Common Stock (1) | |
| Nadav Friedmann | Director, Chief Operating Officer | Other type of transaction at price $ 0.00 per share. | 01 Nov 2011 | 596 | 259,851 | - | - | Common Stock (1) | |
| Peter S. Roddy | Chief Financial Officer | Other type of transaction at price $ 0.00 per share. | 01 Nov 2011 | 192 | 54,942 | - | - | Common stock (1) | |
| Nadav Friedmann | Director, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 18 Oct 2011 | 25,000 | 259,255 | - | - | Common Stock (1) | |
| Nadav Friedmann | Director, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 30 Sep 2011 | 10,000 | 299,255 | - | - | Common Stock (1) | |
| Nadav Friedmann | Director, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 30 Sep 2011 | 8,000 | 291,255 | - | - | Common Stock (2) | |
| Nadav Friedmann | Director, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 30 Sep 2011 | 7,000 | 284,255 | - | - | Common Stock (3) | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2011 | 15,000 | 385,000 | - | - | Non_Qualified Stock Options (1) | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2011 | 15,000 | 492,804 | - | - | Non-Qualified Stock Options (1) | |
| Patrick J. Scannon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 16 Sep 2011 | 15,000 | 200,000 | - | - | Non-Qualified Stock Options (1) | |
| Nadav Friedmann | Director, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 15 Sep 2011 | 25,000 | 309,255 | - | - | Common Stock (1) | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 08 Aug 2011 | 5,000 | 5,948,053 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2011 | 200,000 | 2,659,990 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2011 | 425,084 | 3,084,074 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2011 | 200,000 | 306,752 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 05 Jul 2011 | 146,862 | 453,614 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 05 Jul 2011 | 305,725 | 334,255 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 05 Jul 2011 | 425,084 | 28,530 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Jun 2011 | 200,000 | 2,459,990 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 22 Jun 2011 | 200,000 | 653,614 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 22 Jun 2011 | 146,862 | 506,752 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2011 | 70,000 | 887,024 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2011 | 150,000 | 3,181,864 | - | - | Stock options | |
| Nadav Friedmann | Director, Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2011 | 425,084 | 2,659,990 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2011 | 96,790 | 3,085,074 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 01 Jun 2011 | 305,725 | 453,614 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2011 | 96,790 | 383,812 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 01 Jun 2011 | 425,084 | 759,339 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 01 Jun 2011 | 49,557 | 334,255 | - | - | Common Stock | |
| Peter S. Roddy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2011 | 70,000 | 1,106,866 | - | - | Stock Options | |
| Remi Barbier | Director, Chief Executive Officer/Chairm, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Jun 2011 | 300,000 | 4,237,492 | - | - | Stock Options | |
| Michael J. O'Donnell | None | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 19 May 2011 | 24,618 | 13,968 | - | - | Common Stock | |
| Michael J. O'Donnell | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 May 2011 | 32,811 | 295,308 | - | - | Non-Qualifying Stock Option | |
| Michael J. O'Donnell | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 19 May 2011 | 32,811 | 38,586 | - | - | Common Stock | |
| Michael J. O'Donnell | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2011 | 25,000 | 320,308 | - | - | Non-Qualifying Stock Option | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2011 | 25,000 | 477,804 | - | - | Non-Qualifying Stock Options | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2011 | 25,000 | 477,804 | - | - | Non-Qualifying Stock Option | |
| Patrick J. Scannon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 19 May 2011 | 25,000 | 234,996 | - | - | Non-Qualifying Stock Options | |
| Nadav Friedmann | Director, Chief Operating Officer | Other type of transaction at price $ 0.00 per share. | 02 May 2011 | 4,357 | 287,022 | - | - | Common Stock | |
| Peter S. Roddy | Chief Financial Officer | Other type of transaction at price $ 0.00 per share. | 02 May 2011 | 5,228 | 61,750 | - | - | Common Stock | |
| Peter S. Roddy | Chief Financial Officer | Gift of securities by or to the insider at price $ 0.00 per share. | 02 May 2011 | 7,000 | 54,750 | - | - | Common Stock | |
| Sanford R. Robertson | None | 29 Mar 2011 | 32,811 | 276,830 | - | - | Common Stock | ||
| Sanford R. Robertson | None | 29 Mar 2011 | 32,811 | 337,189 | - | - | Common Stock | ||
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Gift of securities by or to the insider at price $ 0.00 per share. | 04 Mar 2011 | 20,900 | 5,942,473 | - | - | Common Stock | |
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Gift of securities by or to the insider at price $ 0.00 per share. | 04 Mar 2011 | 7,600 | 55,975 | - | - | Common Stock | |
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2011 | 1,968 | 3,937,492 | - | - | Common Stock | |
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 04 Mar 2011 | 1,388 | 5,943,053 | - | - | Common Stock | |
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 04 Mar 2011 | 1,968 | 5,944,441 | - | - | Common Stock | |
| Grant L. Schoenhard | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2011 | 67,592 | 817,024 | - | - | Common Stock | |
| Grant L. Schoenhard | None | Payment of exercise price or tax liability using portion of securities received from the company at price $ 0.00 per share. | 28 Feb 2011 | 60,280 | 55,499 | - | - | Common Stock | |
| Grant L. Schoenhard | None | Exercise or conversion of derivative security received from the company (such as an option) at price $ 0.00 per share. | 28 Feb 2011 | 67,592 | 115,779 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Dec 2010 | 4,826 | 282,665 | - | - | Common Stock | |
| Peter S. Roddy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Dec 2010 | 12,465 | 56,522 | - | - | Common Stock | |
| Remi Barbier | Director, CEO, Chairman of the Board, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 23 Dec 2010 | 33,786 | 5,963,373 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Other type of transaction at price $ 0.00 per share. | 01 Nov 2010 | 1,888 | 277,839 | - | - | Common Stock | |
| Peter S. Roddy | Chief Financial Officer | Other type of transaction at price $ 0.00 per share. | 01 Nov 2010 | 1,661 | 44,057 | - | - | Common Stock | |
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Oct 2010 | 35,000 | 5,944,587 | - | - | Common Stock | |
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Oct 2010 | 15,000 | 5,929,587 | - | - | Common Stock | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Sep 2010 | 15,000 | 345,000 | - | - | Non-Qualified Stock Options | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Sep 2010 | 15,000 | 370,000 | - | - | Non-Qualified Stock Options | |
| Patrick J. Scannon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 17 Sep 2010 | 15,000 | 160,000 | - | - | Non-Qualified Stock Options | |
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 03 Sep 2010 | 16,264 | 5,979,587 | - | - | Common Stock | |
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 03 Sep 2010 | 12,333 | 5,995,851 | - | - | Common Stock | |
| Grant L. Schoenhard | Director, Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Sep 2010 | 70,000 | 724,000 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Sep 2010 | 150,000 | 2,310,000 | - | - | Stock Options | |
| Peter S. Roddy | Director, Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Sep 2010 | 70,000 | 790,000 | - | - | Stock Options | |
| Remi Barbier | Director, CEO &Chairman of the Board, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 01 Sep 2010 | 300,000 | 3,001,500 | - | - | Stock Options | |
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Sep 2010 | 11,097 | 6,008,184 | - | - | Common Stock | |
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Sep 2010 | 10,306 | 6,019,281 | - | - | Common Stock | |
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 05 Aug 2010 | 9,496 | 6,036,055 | - | - | Common Stock | |
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 05 Aug 2010 | 6,468 | 6,029,587 | - | - | Common Stock | |
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 05 Aug 2010 | 3,505 | 6,045,551 | - | - | Common Stock | |
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 Aug 2010 | 9,352 | 6,062,095 | - | - | Common Stock | |
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 Aug 2010 | 6,582 | 6,049,056 | - | - | Common Stock | |
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 Aug 2010 | 6,457 | 6,055,638 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 16 Jul 2010 | 1,500 | 48,157 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | 16 Jul 2010 | 1,500 | 49,687 | - | - | Common Stock | ||
| Grant L. Schoenhard | Chief Scientific Officer | 16 Jul 2010 | 1,500 | 654,000 | - | - | Common Stock | ||
| Remi Barbier | Director, CEO and Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 06 Jul 2010 | 20,172 | 6,078,518 | - | - | Common Stock | |
| Remi Barbier | Director, CEO and Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 06 Jul 2010 | 7,071 | 6,071,447 | - | - | Common Stock | |
| Remi Barbier | Director, CEO and Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Jul 2010 | 11,692 | 6,109,755 | - | - | Common Stock | |
| Remi Barbier | Director, CEO and Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Jul 2010 | 11,065 | 6,098,690 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 16 Jun 2010 | 1,500 | 48,187 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | 16 Jun 2010 | 1,500 | 655,500 | - | - | Common Stock | ||
| Grant L. Schoenhard | Chief Scientific Officer | 16 Jun 2010 | 1,500 | 49,687 | - | - | Common Stock | ||
| Remi Barbier | Director, CEO and Chairman of Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Jun 2010 | 27,673 | 6,143,774 | - | - | Common Stock | |
| Remi Barbier | Director, CEO and Chairman of Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Jun 2010 | 14,089 | 6,129,685 | - | - | Common Stock | |
| Remi Barbier | Director, CEO and Chairman of Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Jun 2010 | 8,238 | 6,121,447 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | 27 May 2010 | 10,979 | 657,000 | - | - | Common Stock | ||
| Grant L. Schoenhard | Chief Scientific Officer | 27 May 2010 | 10,979 | 59,166 | - | - | Common Stock | ||
| Grant L. Schoenhard | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 27 May 2010 | 10,979 | 48,187 | - | - | Common Stock | |
| Michael J. O'Donnell | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2010 | 25,000 | 275,000 | - | - | Non-Qualified Stock Option | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2010 | 25,000 | 330,000 | - | - | Non-Qualified Stock Options | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 20 May 2010 | 25,000 | 355,000 | - | - | Non-Qualified Stock Options | |
| Grant L. Schoenhard | Chief Scientific Officer | 19 May 2010 | 2,486 | 50,673 | - | - | Common Stock | ||
| Grant L. Schoenhard | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 19 May 2010 | 2,486 | 48,187 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | 19 May 2010 | 2,486 | 667,979 | - | - | Common Stock | ||
| Grant L. Schoenhard | Chief Scientific Officer | 17 May 2010 | 7,926 | 670,465 | - | - | Common Stock | ||
| Grant L. Schoenhard | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 17 May 2010 | 7,926 | 48,187 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | 17 May 2010 | 1,500 | 682,000 | - | - | Common Stock | ||
| Grant L. Schoenhard | Chief Scientific Officer | 17 May 2010 | 7,926 | 61,222 | - | - | Common Stock | ||
| Grant L. Schoenhard | Chief Scientific Officer | 17 May 2010 | 1,500 | 49,687 | - | - | Common Stock | ||
| Grant L. Schoenhard | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 17 May 2010 | 5,109 | 5,611 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | 17 May 2010 | 3,609 | 53,296 | - | - | Common Stock | ||
| Grant L. Schoenhard | Chief Scientific Officer | 17 May 2010 | 3,609 | 678,391 | - | - | Common Stock | ||
| Remi Barbier | Director, CEO and Chairman of BOD, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 06 May 2010 | 6,576 | 6,171,447 | - | - | Common Stock | |
| Peter S. Roddy | Chief Financial Officer | Other type of transaction at price $ 0.00 per share. | 03 May 2010 | 3,983 | 42,396 | - | - | Common Stock | |
| Remi Barbier | Director, CEO and Chairman of BOD, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 03 May 2010 | 11,924 | 6,209,523 | - | - | Common Stock | |
| Remi Barbier | Director, CEO and Chairman of BOD, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 03 May 2010 | 11,400 | 6,198,123 | - | - | Common Stock | |
| Remi Barbier | Director, CEO and Chairman of BOD, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 03 May 2010 | 20,100 | 6,178,023 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 May 2010 | 15,000 | 275,951 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Other type of transaction at price $ 0.00 per share. | 01 May 2010 | 3,756 | 290,951 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | 16 Apr 2010 | 25,000 | 74,687 | - | - | Common Stock | ||
| Grant L. Schoenhard | Chief Scientific Officer | 16 Apr 2010 | 1,500 | 49,687 | - | - | Common Stock | ||
| Grant L. Schoenhard | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 16 Apr 2010 | 26,500 | 48,187 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | 16 Apr 2010 | 25,000 | 683,500 | - | - | Common Stock | ||
| Grant L. Schoenhard | Chief Scientific Officer | 16 Apr 2010 | 1,500 | 708,500 | - | - | Common Stock | ||
| Remi Barbier | Director, CEO and Chairman of Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 07 Apr 2010 | 5,800 | 6,221,447 | - | - | Common Stock | |
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 05 Apr 2010 | 22,200 | 6,227,247 | - | - | common stock | |
| Remi Barbier | Director, CEO & Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 05 Apr 2010 | 10,000 | 6,249,447 | - | - | Common Stock | |
| Nadav Friedmann | Director, COO | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Apr 2010 | 15,000 | 287,195 | - | - | Common Stock | |
| Remi Barbier | Director, CEO and Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Apr 2010 | 12,000 | 6,259,447 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 16 Mar 2010 | 10,000 | 58,187 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 16 Mar 2010 | 25,000 | 83,187 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 16 Mar 2010 | 35,000 | 48,187 | - | - | Common Stock | |
| Grant L. Schoenhard | Chief Scientific Officer | 16 Mar 2010 | 25,000 | 720,000 | - | - | Common Stock | ||
| Grant L. Schoenhard | Chief Scientific Officer | 16 Mar 2010 | 10,000 | 710,000 | - | - | Common Stock | ||
| Michael J. O'Donnell | None | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 11 Mar 2010 | 25,000 | 5,775 | - | - | Common Stock | |
| Remi Barbier | Director, CEO and Chair of Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 03 Mar 2010 | 5,443 | 6,271,447 | - | - | Common Stock | |
| Michael J. O'Donnell | None | 25 Feb 2010 | 25,000 | 225,000 | - | - | Common Stock | ||
| Michael J. O'Donnell | None | 25 Feb 2010 | 25,000 | 30,775 | - | - | Common Stock | ||
| Remi Barbier | Director, CEO and Chair of the Board, Ten Percent Owner | Gift of securities by or to the insider at price $ 0.00 per share. | 02 Feb 2010 | 9,600 | 48,375 | - | - | Common Stock | |
| Remi Barbier | Director, CEO and Chair of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 Feb 2010 | 14,667 | 6,276,890 | - | - | Common Stock | |
| Remi Barbier | Director, CEO and Chair of the Board, Ten Percent Owner | Gift of securities by or to the insider at price $ 0.00 per share. | 02 Feb 2010 | 28,800 | 6,321,447 | - | - | Common Stock | |
| Remi Barbier | Director, CEO and Chair of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 Feb 2010 | 29,890 | 6,291,557 | - | - | Common stock | |
| Remi Barbier | Director, CEO, President, Chairman of Bd, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Feb 2010 | 20,200 | 6,350,247 | - | - | Common Stock | |
| Remi Barbier | Director, CEO, President, Chairman of Bd, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Feb 2010 | 29,800 | 6,370,447 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Medical Officer | Other type of transaction at price $ 0.00 per share. | 19 Jan 2010 | 14,937 | 302,195 | - | - | Common Stock | |
| Peter S. Roddy | None | Other type of transaction at price $ 0.00 per share. | 19 Jan 2010 | 8,630 | 38,413 | - | - | Common Stock | |
| Remi Barbier | Director, CEO, President and Chairman of, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 19 Jan 2010 | 27,772 | 6,400,247 | - | - | Common Stock | |
| Remi Barbier | Director, CEO, Chairman of Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 04 Jan 2010 | 15,900 | 6,406,575 | - | - | Common Stock | |
| Remi Barbier | Director, CEO, Chairman of Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 04 Jan 2010 | 19,600 | 6,386,975 | - | - | Common Stock | |
| Remi Barbier | Director, CEO, Chairman of Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 04 Jan 2010 | 14,500 | 6,372,475 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 07 Dec 2009 | 15,000 | 287,258 | - | - | Common Stock | |
| Nadav Friedmann | Director, Chief Operating Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 16 Nov 2009 | 15,000 | 302,258 | - | - | Common Stock | |
| Remi Barbier | Director, Chief Executive Officer,, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 Nov 2009 | 10,000 | 6,512,475 | - | - | Common Stock | |
| Remi Barbier | Director, Chief Executive Officer,, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 Nov 2009 | 10,000 | 6,472,475 | - | - | Common Stock | |
| Remi Barbier | Director, Chief Executive Officer,, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 Nov 2009 | 15,000 | 6,497,475 | - | - | Common Stock | |
| Remi Barbier | Director, Chief Executive Officer,, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 Nov 2009 | 15,000 | 6,482,475 | - | - | Common Stock | |
| Sanford R. Robertson | None | 15 Oct 2009 | 50,000 | 330,000 | - | - | Common Stock | ||
| Sanford R. Robertson | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 15 Oct 2009 | 50,000 | 244,019 | - | - | Common Stock | |
| Remi Barbier | Director, CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 05 Oct 2009 | 10,000 | 6,542,475 | - | - | Common Stock | |
| Remi Barbier | Director, CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 05 Oct 2009 | 10,000 | 6,532,475 | - | - | Common Stock | |
| Remi Barbier | Director, CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 05 Oct 2009 | 10,000 | 6,522,475 | - | - | Common Stock | |
| Remi Barbier | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Oct 2009 | 10,000 | 6,562,475 | - | - | Common Stock | |
| Remi Barbier | Director, Chief Executive Officer, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 01 Oct 2009 | 10,000 | 6,552,475 | - | - | Common Stock | |
| Remi Barbier | Director, CEO and Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 14 Sep 2009 | 7,800 | 6,591,475 | - | - | Common Stock | |
| Remi Barbier | Director, CEO and Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 14 Sep 2009 | 10,000 | 6,581,475 | - | - | Common Stock | |
| Remi Barbier | Director, CEO and Chairman of the Board, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 14 Sep 2009 | 9,000 | 6,572,475 | - | - | Common Stock | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Sep 2009 | 15,000 | 305,000 | - | - | Non-Qualified Stock Options | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Sep 2009 | 15,000 | 380,000 | - | - | Non-Qualified Stock Option | |
| Patrick J. Scannon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 11 Sep 2009 | 15,000 | 120,000 | - | - | Non-Qualified Stock Option | |
| Remi Barbier | Director, CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 10 Sep 2009 | 15,900 | 6,606,575 | - | - | Common Stock | |
| Remi Barbier | Director, CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 10 Sep 2009 | 7,300 | 6,599,275 | - | - | Common Stock | |
| Peter S. Roddy | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 31 Aug 2009 | 40,000 | 94,783 | - | - | Common Stock (1) | |
| Peter S. Roddy | Chief Financial Officer | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 31 Aug 2009 | 40,000 | 54,783 | - | - | Common Stock (1) | |
| Peter S. Roddy | Chief Financial Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 31 Aug 2009 | 40,000 | 720,000 | - | - | Stock options (1) | |
| Grant L. Schoenhard | Chief Scientific Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jul 2009 | 70,000 | 745,000 | - | - | Stock Option | |
| Nadav Friedmann | Director, Chief Operating Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jul 2009 | 150,000 | 2,160,000 | - | - | Stock Options | |
| Peter S. Roddy | Chief Financial Officer | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jul 2009 | 70,000 | 760,000 | - | - | Stock Options | |
| Remi Barbier | Director, Chief Executive Officer, Ten Percent Owner | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Jul 2009 | 32,400 | 6,611,675 | - | - | Common Stock | |
| Remi Barbier | Director, Chief Executive Officer, Ten Percent Owner | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 31 Jul 2009 | 300,000 | 2,701,500 | - | - | Stock Options | |
| Remi Barbier | Director, Chief Executive Officer, Ten Percent Owner | Gift of securities by or to the insider at price $ 0.00 per share. | 31 Jul 2009 | 10,800 | 6,622,475 | - | - | Common Stock | |
| Remi Barbier | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 04 Jun 2009 | 25,000 | 6,669,075 | - | - | Common Stock | |
| Remi Barbier | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 04 Jun 2009 | 25,000 | 6,644,075 | - | - | Common Stock | |
| Michael J. O'Donnell | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2009 | 25,000 | 250,000 | - | - | Non-Qualifying Stock Options | |
| Robert Z. Gussin | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2009 | 25,000 | 290,000 | - | - | Non Qualifying Stock Option | |
| Sanford R. Robertson | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2009 | 25,000 | 365,000 | - | - | Non-Qualifying Stock Option | |
| Patrick J. Scannon | None | Grant, award, or other acquisition of securities at price $ 0.00 per share. | 21 May 2009 | 25,000 | 105,000 | - | - | Non-Qualifying Stock Options | |
| Nadav Friedmann | Director, Chief Operating Officer | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 01 May 2009 | 3,374 | 317,258 | - | - | Common Stock | |
| Peter S. Roddy | Vice President & CFO | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 01 May 2009 | 3,374 | 54,783 | - | - | Common Stock | |
| Sanford R. Robertson | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 04 Mar 2009 | 25,000 | 194,019 | - | - | Common Stock | |
| Sanford R. Robertson | None | Purchase of securities on an exchange or from another person at price $ 0.00 per share. | 04 Mar 2009 | 25,000 | 340,000 | - | - | Common Stock | |
| Remi Barbier | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 Feb 2009 | 25,000 | 6,719,075 | - | - | Common Stock | |
| Remi Barbier | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 Feb 2009 | 25,000 | 6,694,075 | - | - | Common Stock | |
| Remi Barbier | Director, President and CEO, Ten Percent Owner | Other type of transaction at price $ 0.00 per share. | 02 Feb 2009 | 14,000 | 168,700 | - | - | Common Stock | |
| Remi Barbier | Director, President and CEO, Ten Percent Owner | Sale of securities on an exchange or to another person at price $ 0.00 per share. | 02 Jan 2009 | 25,000 | 6,769,075 | - | - | Common Stock |